(1) Cellular and innate immunity status must be "ready" in the present COVID-19 pandemic situation.
For this purpose, it is important to receive adequate non-specific immune stimulation(s) (not necessarily using antigen(s) of target pathogen).
In the modern urban areas, such there is an absolute lack of such good stimulation(s) from nature.
In the modern urban areas, such there is an absolute lack of such good stimulation(s) from nature.
(2) In order to increase the level of humoral immunity, specific immune stimulation to B cells with the antigen consisting of the target pathogen is necessary. (In the case of mRNA vaccines, mRNA in the vaccines is translated into the specific protein (=produced antigen) in the body that triggers the antibody production.)
It is important to note that (1) and (2) are very different in terms of enhancing immune levels in the first step of the prevention of COVID-19 and other various infections.
As the virus (such as SARS-CoV-2) mutates, the antibodies produced against the original antigen eventually become ineffective (=breakthrough infection).
👉Naiive macrophages cannot efficiently cope with newly encountered viruses. It is necessary to prime macrophages by adequate immunological stimulus, such as BCG (=trained immunity).
👉Lack of exercise makes you unhealthy.
Adequtate exercise is necessary.
Lack of immunological stimulation(s) also makes you unhealthy.
Adequate Immunological stimulation(s) including BCG might be necessary for maintaining your health.
👉 In the clean and highly sanitary countries, the hygiene hypothesis (or old friend hypothesis) explains that there are few infectious diseases but high frequency of allergic diseases, autoimmune diseases, and/or cancers. In those countries, it is speculated that the low level of stimulation for cellular and innate immunity that is routinely received from the environment (partly due to the lack of BCG vaccination) might be a factor in the severity of COVID-19.
👉When you boost cellular and innate immunity levels, your skin will be smoother and shinier; accordingly, your skin defenses against unknown viruses will be augmented.
👉It is thoroughly cleaned and sanitized as a measure against SARS-CoV-2. As a result, it should be reminded that frequency and severity of various allergic diseases (= side effects of cleaning and sanitization) will increase in modern urban areas.